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BRAF inhibitors stimulate inflammasome activation and interleukin 1 beta production in dendritic cells

Melanoma is the most dangerous form of skin cancer with a growing incidence over the last decades. Fourty percent of all melanomas harbor a mutation in the signaling adaptor BRAF (V600E) that results in ERK hyperactivity as an oncogenic driver. In these cases, treatment with the BRAF(V600E) inhibito...

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Detalles Bibliográficos
Autores principales:	Hajek, Eva, Krebs, Franziska, Bent, Rebekka, Haas, Katharina, Bast, Antje, Steinmetz, Ivo, Tuettenberg, Andrea, Grabbe, Stephan, Bros, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper: Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033361/ https://www.ncbi.nlm.nih.gov/pubmed/29983861 http://dx.doi.org/10.18632/oncotarget.25511

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