Inhibition of NF-κB signaling in IKKβ(F/F);LysM Cre mice causes motor deficits but does not alter pathogenesis of Spinocerebellar ataxia type 1

Spinocerebellar Ataxia type 1 (SCA1) is a fatal neurodegenerative genetic disease that is characterized by pronounced neuronal loss and gliosis in the cerebellum. We have previously demonstrated microglial activation, measured as an increase in microglial density in cerebellar cortex and an increase...

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Detalles Bibliográficos
Autores principales: Ferro, Austin, Qu, Wenhui, Lukowicz, Abigail, Svedberg, Daniel, Johnson, Andrea, Cvetanovic, Marija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033432/
https://www.ncbi.nlm.nih.gov/pubmed/29975753
http://dx.doi.org/10.1371/journal.pone.0200013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033432/
https://www.ncbi.nlm.nih.gov/pubmed/29975753
http://dx.doi.org/10.1371/journal.pone.0200013

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