TASEP modelling provides a parsimonious explanation for the ability of a single uORF to derepress translation during the integrated stress response

Translation initiation is the rate-limiting step of protein synthesis that is downregulated during the Integrated Stress Response (ISR). Previously, we demonstrated that most human mRNAs that are resistant to this inhibition possess translated upstream open reading frames (uORFs), and that in some c...

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Detalles Bibliográficos
Autores principales: Andreev, Dmitry E, Arnold, Maxim, Kiniry, Stephen J, Loughran, Gary, Michel, Audrey M, Rachinskii, Dmitrii, Baranov, Pavel V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033536/
https://www.ncbi.nlm.nih.gov/pubmed/29932418
http://dx.doi.org/10.7554/eLife.32563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033536/
https://www.ncbi.nlm.nih.gov/pubmed/29932418
http://dx.doi.org/10.7554/eLife.32563

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