H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers

Expression of histone H3.3K27M mutant proteins in human diffuse intrinsic pontine glioma (DIPG) results in a global reduction of tri-methylation of H3K27 (H3K27me3), and paradoxically, H3K27me3 peaks remain at hundreds of genomic loci, a dichotomous change that lacks mechanistic insights. Here, we s...

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Detalles Bibliográficos
Autores principales: Fang, Dong, Gan, Haiyun, Cheng, Liang, Lee, Jeong-Heon, Zhou, Hui, Sarkaria, Jann N, Daniels, David J, Zhang, Zhiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033537/
https://www.ncbi.nlm.nih.gov/pubmed/29932419
http://dx.doi.org/10.7554/eLife.36696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033537/
https://www.ncbi.nlm.nih.gov/pubmed/29932419
http://dx.doi.org/10.7554/eLife.36696

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