The eukaryotic bell-shaped temporal rate of DNA replication origin firing emanates from a balance between origin activation and passivation

The time-dependent rate [Formula: see text] of origin firing per length of unreplicated DNA presents a universal bell shape in eukaryotes that has been interpreted as the result of a complex time-evolving interaction between origins and limiting firing factors. Here, we show that a normal diffusion...

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Detalles Bibliográficos
Autores principales: Arbona, Jean-Michel, Goldar, Arach, Hyrien, Olivier, Arneodo, Alain, Audit, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033540/
https://www.ncbi.nlm.nih.gov/pubmed/29856315
http://dx.doi.org/10.7554/eLife.35192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033540/
https://www.ncbi.nlm.nih.gov/pubmed/29856315
http://dx.doi.org/10.7554/eLife.35192

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