The Act1 D10N Missense Variant Impairs CD40 Signaling in Human B-Cells

The TRAF3IP2 gene resides within one of at least 63 psoriasis susceptibility loci and encodes Act1, an adapter protein involved in IL-17 receptor and CD40 signaling pathways. TRAF3IP2 is distinctive (among <10% of candidate susceptibility genes) in that a strongly disease-associated variant encod...

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Detalles Bibliográficos
Autores principales: Yu, Ning, Lambert, Sylviane, Bornstein, Joshua, Nair, Rajan P., Enerbäck, Charlotta, Elder, James T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033699/
https://www.ncbi.nlm.nih.gov/pubmed/29302052
http://dx.doi.org/10.1038/s41435-017-0007-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033699/
https://www.ncbi.nlm.nih.gov/pubmed/29302052
http://dx.doi.org/10.1038/s41435-017-0007-7

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