Preventive treatment with liraglutide protects against development of glucose intolerance in a rat model of Wolfram syndrome

Wolfram syndrome (WS) is a rare autosomal recessive disorder caused by mutations in the WFS1 (Wolframin1) gene. The syndrome first manifests as diabetes mellitus, followed by optic nerve atrophy, deafness, and neurodegeneration. The underlying mechanism is believed to be a dysregulation of endoplasm...

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Detalles Bibliográficos
Autores principales: Toots, Maarja, Seppa, Kadri, Jagomäe, Toomas, Koppel, Tuuliki, Pallase, Maia, Heinla, Indrek, Terasmaa, Anton, Plaas, Mario, Vasar, Eero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033861/
https://www.ncbi.nlm.nih.gov/pubmed/29976929
http://dx.doi.org/10.1038/s41598-018-28314-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033861/
https://www.ncbi.nlm.nih.gov/pubmed/29976929
http://dx.doi.org/10.1038/s41598-018-28314-z

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