Cargando…

Dietary fat-associated osteoarthritic chondrocytes gain resistance to lipotoxicity through PKCK2/STAMP2/FSP27

Free fatty acids (FFAs), which are elevated with metabolic syndrome, are considered the principal offender exerting lipotoxicity. Few previous studies have reported a causal relationship between FFAs and osteoarthritis pathogenesis. However, the molecular mechanism by which FFAs exert lipotoxicity a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Sung Won, Rho, Jee Hyun, Lee, Sang Yeob, Chung, Won Tae, Oh, Yoo Jin, Kim, Jung Ha, Yoo, Seung Hee, Kwon, Woo Young, Bae, Ju Yong, Seo, Su Young, Sun, Hokeun, Kim, Hye Young, Yoo, Young Hyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033867/ https://www.ncbi.nlm.nih.gov/pubmed/30002945 http://dx.doi.org/10.1038/s41413-018-0020-0

Ejemplares similares

Alpha B-Crystallin Protects Rat Articular Chondrocytes against Casein Kinase II Inhibition-Induced Apoptosis
por: Lee, Sung Won, et al.
Publicado: (2016)

STAMPing into Mitochondria
por: Yoo, Seong Keun, et al.
Publicado: (2014)

The Role of STAMP2 in Pathogenesis of Chronic Diseases Focusing on Nonalcoholic Fatty Liver Disease: A Review
por: Kim, Hye Young, et al.
Publicado: (2022)

Hepatic Steatosis Alleviated in Diabetic Mice upon Dietary Exposure to Fibroin via Transgenic Rice: Potential STAMP2 Involvement in Hepatocytes
por: Park, Ji-Eun, et al.
Publicado: (2020)

Hepatic STAMP2 decreases hepatitis B virus X protein-associated metabolic deregulation
por: Kim, Hye Young, et al.
Publicado: (2012)

Downregulation of Protein Kinase CK2 Activity Facilitates Tumor Necrosis Factor-α-Mediated Chondrocyte Death through Apoptosis and Autophagy
por: Lee, Sung Won, et al.
Publicado: (2011)

Cilostazol induces cellular senescence and confers resistance to etoposide-induced apoptosis in articular chondrocytes
por: KIM, KANG MI, et al.
Publicado: (2012)

Anti-Osteoarthritic Mechanisms of Chrysanthemum zawadskii var. latilobum in MIA-Induced Osteoarthritic Rats and Interleukin-1β-Induced SW1353 Human Chondrocytes
por: Byun, Jae-Hyuk, et al.
Publicado: (2020)

Effect of electromagnetic fields on human osteoarthritic and non-osteoarthritic chondrocytes
por: Redeker, Julia Isabelle, et al.
Publicado: (2017)

The effect of resveratrol on normal and osteoarthritic chondrocyte metabolism
por: Kim, H. J., et al.
Publicado: (2014)

Lipotoxicity of Palmitic Acid on Neural Progenitor Cells and Hippocampal Neurogenesis
por: Park, Hee Ra, et al.
Publicado: (2011)

Cytoplasmic and Nuclear Anti-Apoptotic Roles of αB-Crystallin in Retinal Pigment Epithelial Cells
por: Jeong, Woo Jin, et al.
Publicado: (2012)

Effect of Omega-3 Fatty Acid on STAMP2 Expression in the Heart and Kidney of 5/6 Nephrectomy Rat Model
por: Lee, Hye Won, et al.
Publicado: (2018)

Identification of the calcitonin receptor in osteoarthritic chondrocytes
por: Segovia-Silvestre, Toni, et al.
Publicado: (2011)

Irisin Recovers Osteoarthritic Chondrocytes In Vitro
por: Vadalà, Gianluca, et al.
Publicado: (2020)

Eucommia ulmoides Cortex, Geniposide and Aucubin Regulate Lipotoxicity through the Inhibition of Lysosomal BAX
por: Lee, Geum-Hwa, et al.
Publicado: (2014)

Prevalence of Obesity and Incidence of Obesity-Related Comorbidities in Koreans Based on National Health Insurance Service Health Checkup Data 2006–2015 (J Obes Metab Syndr 2018;27:46–52)
por: Seo, Mi Hae, et al.
Publicado: (2018)

Direct Acting Antiviral Agents in Korean Patients with Chronic Hepatitis C and Hemophilia Who Are Treatment-Naïve or Treatment-Experienced
por: Lee, Hyun Woong, et al.
Publicado: (2017)

Lipid droplets fatten up with Fsp27
por: Short, Ben
Publicado: (2011)

Safety Evaluation of Stamp Type Digital Microneedle Devices in Hairless Mice
por: Park, Kui Young, et al.
Publicado: (2013)

Persistent Organic Pollutant-Mediated Insulin Resistance
por: Kim, Yeon A., et al.
Publicado: (2019)

Protective effects of aucubin on osteoarthritic chondrocyte model induced by hydrogen peroxide and mechanical stimulus
por: Young, In-Chi, et al.
Publicado: (2017)

Cell biology and functional genomics of osteoarthritic chondrocytes
por: Aigner, T, et al.
Publicado: (2003)

Biological Effects of Phosphocitrate on Osteoarthritic Articular Chondrocytes
por: Sun, Yubo, et al.
Publicado: (2017)

Clusterin Protects Lipotoxicity-Induced Apoptosis via Upregulation of Autophagy in Insulin-Secreting Cells
por: Hong, Seok-Woo, et al.
Publicado: (2020)

Solution-free and simplified H&E staining using a hydrogel-based stamping technology
por: Kim, Jinho, et al.
Publicado: (2023)

Macrolide Resistance and Its Impacts on M. Pneumoniae Pneumonia in Children: Comparison of Two Recent Epidemics in Korea
por: Kim, Jong Hyun, et al.
Publicado: (2017)

The effectiveness of an enhanced recovery after surgery protocol in head and neck cancer surgery with free-flap reconstruction
por: Won, Ho-Ryun, et al.
Publicado: (2019)

Therapeutic silencing of FSP27 reduces the progression of atherosclerosis in Ldlr(−/−) mice
por: Rajamoorthi, Ananthi, et al.
Publicado: (2018)

Changes of lipid profiles after radical gastrectomy in patients with gastric cancer
por: Lee, Jin Won, et al.
Publicado: (2015)

PEP-1-FK506BP12 inhibits matrix metalloproteinase expression in human articular chondrocytes and in a mouse carrageenan-induced arthritis model
por: Hwang, Hyun Sook, et al.
Publicado: (2015)

Detecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA
por: Crowe, N., et al.
Publicado: (2016)

Senescence of Nucleus Pulposus Chondrocytes in Human Intervertebral Discs
por: Kim, Ki-Won, et al.
Publicado: (2008)

Proliferation and differentiation potential of chondrocytes from osteoarthritic patients
por: Tallheden, Tommi, et al.
Publicado: (2005)

Toll-like receptors in human chondrocytes and osteoarthritic cartilage
por: Sillat, Tarvo, et al.
Publicado: (2013)

Anti-Osteoarthritic Effects of Antarctic Krill Oil in Primary Chondrocytes and a Surgical Rat Model of Knee Osteoarthritis
por: Ku, Sae-Kwang, et al.
Publicado: (2023)

Recombinant FGF21 Attenuates Polychlorinated Biphenyl-Induced NAFLD/NASH by Modulating Hepatic Lipocalin-2 Expression
por: Kim, Hye Young, et al.
Publicado: (2022)

The effects of intra-articular resiniferatoxin on monosodium iodoacetate-induced osteoarthritic pain in rats
por: Kim, Youngkyung, et al.
Publicado: (2016)

Avenanthramide C as a novel candidate to alleviate osteoarthritic pathogenesis
por: Tran, Thanh-Tam, et al.
Publicado: (2021)

The Fate of Partially Thrombosed Intracranial Aneurysms Treated with Endovascular Intervention
por: Lee, Jeongjun, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7iql4r9189j7ncg067as3qrdom