Discovery of Mcl-1 inhibitors from integrated high throughput and virtual screening

Protein-protein interactions (PPIs) represent important and promising therapeutic targets that are associated with the regulation of various molecular pathways, particularly in cancer. Although they were once considered “undruggable,” the recent advances in screening strategies, structure-based desi...

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Detalles Bibliográficos
Autores principales: Mady, Ahmed S. A., Liao, Chenzhong, Bajwa, Naval, Kump, Karson J., Abulwerdi, Fardokht A., Lev, Katherine L., Miao, Lei, Grigsby, Sierrah M., Perdih, Andrej, Stuckey, Jeanne A., Du, Yuhong, Fu, Haian, Nikolovska-Coleska, Zaneta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033896/
https://www.ncbi.nlm.nih.gov/pubmed/29976942
http://dx.doi.org/10.1038/s41598-018-27899-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033896/
https://www.ncbi.nlm.nih.gov/pubmed/29976942
http://dx.doi.org/10.1038/s41598-018-27899-9

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