Enantioselective pharmacokinetics of tramadol and its three main metabolites; impact of CYP2D6, CYP2B6, and CYP3A4 genotype

Tramadol is a complex drug, being metabolized by polymorphic enzymes and administered as a racemate with the (+)‐ and (−)‐enantiomers of the parent compound and metabolites showing different pharmacological effects. The study aimed to simultaneously determine the enantiomer concentrations of tramado...

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Detalles Bibliográficos
Autores principales: Haage, Pernilla, Kronstrand, Robert, Josefsson, Martin, Calistri, Simona, van Schaik, Ron H. N., Green, Henrik, Kugelberg, Fredrik C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034060/
https://www.ncbi.nlm.nih.gov/pubmed/29992026
http://dx.doi.org/10.1002/prp2.419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034060/
https://www.ncbi.nlm.nih.gov/pubmed/29992026
http://dx.doi.org/10.1002/prp2.419

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