Secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for β cell specification

OBJECTIVE: Specification of endocrine cell lineages in the developing pancreas relies on extrinsic signals from non-pancreatic tissues, which initiate a cell-autonomous sequence of transcription factor activation and repression switches. The steps in this pathway share reliance on activity-dependent...

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Detalles Bibliográficos
Autores principales: Malenczyk, Katarzyna, Szodorai, Edit, Schnell, Robert, Lubec, Gert, Szabó, Gábor, Hökfelt, Tomas, Harkany, Tibor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034064/
https://www.ncbi.nlm.nih.gov/pubmed/29910119
http://dx.doi.org/10.1016/j.molmet.2018.05.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034064/
https://www.ncbi.nlm.nih.gov/pubmed/29910119
http://dx.doi.org/10.1016/j.molmet.2018.05.019

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