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Secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for β cell specification
OBJECTIVE: Specification of endocrine cell lineages in the developing pancreas relies on extrinsic signals from non-pancreatic tissues, which initiate a cell-autonomous sequence of transcription factor activation and repression switches. The steps in this pathway share reliance on activity-dependent...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034064/ https://www.ncbi.nlm.nih.gov/pubmed/29910119 http://dx.doi.org/10.1016/j.molmet.2018.05.019 |