A single amino acid substitution in CXCL12 confers functional selectivity at the beta-arrestin level

CXCL12/CXCR4 axis relies on both heterotrimeric G(i) protein and β-arrestin coupling to trigger downstream responses. G protein activation allows for calcium flux, chemotaxis and early extracellular-signal regulated kinases 1/2 (ERK1/2) phosphorylation, whereas β-arrestin recruitment leads to late s...

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Detalles Bibliográficos
Autores principales: Rigo, Antonella, Ferrarini, Isacco, Innamorati, Giulio, Vinante, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034749/
https://www.ncbi.nlm.nih.gov/pubmed/29989007
http://dx.doi.org/10.18632/oncotarget.25533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034749/
https://www.ncbi.nlm.nih.gov/pubmed/29989007
http://dx.doi.org/10.18632/oncotarget.25533

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