Cargando…
A single amino acid substitution in CXCL12 confers functional selectivity at the beta-arrestin level
CXCL12/CXCR4 axis relies on both heterotrimeric G(i) protein and β-arrestin coupling to trigger downstream responses. G protein activation allows for calcium flux, chemotaxis and early extracellular-signal regulated kinases 1/2 (ERK1/2) phosphorylation, whereas β-arrestin recruitment leads to late s...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034749/ https://www.ncbi.nlm.nih.gov/pubmed/29989007 http://dx.doi.org/10.18632/oncotarget.25533 |