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Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility

Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer mortality in American women. Normal ovarian physiology is intricately connected to small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and Ran) which govern processes such as signal transduction, cell proliferati...

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Autores principales: Earp, Madalene, Tyrer, Jonathan P., Winham, Stacey J., Lin, Hui-Yi, Chornokur, Ganna, Dennis, Joe, Aben, Katja K. H., Anton‐Culver, Hoda, Antonenkova, Natalia, Bandera, Elisa V., Bean, Yukie T., Beckmann, Matthias W., Bjorge, Line, Bogdanova, Natalia, Brinton, Louise A., Brooks-Wilson, Angela, Bruinsma, Fiona, Bunker, Clareann H., Butzow, Ralf, Campbell, Ian G., Carty, Karen, Chang-Claude, Jenny, Cook, Linda S., Cramer, Daniel W, Cunningham, Julie M., Cybulski, Cezary, Dansonka-Mieszkowska, Agnieszka, Despierre, Evelyn, Doherty, Jennifer A., Dörk, Thilo, du Bois, Andreas, Dürst, Matthias, Easton, Douglas F., Eccles, Diana M., Edwards, Robert P., Ekici, Arif B., Fasching, Peter A., Fridley, Brooke L., Gentry-Maharaj, Aleksandra, Giles, Graham G., Glasspool, Rosalind, Goodman, Marc T., Gronwald, Jacek, Harter, Philipp, Hein, Alexander, Heitz, Florian, Hildebrandt, Michelle A. T., Hillemanns, Peter, Hogdall, Claus K., Høgdall, Estrid, Hosono, Satoyo, Iversen, Edwin S., Jakubowska, Anna, Jensen, Allan, Ji, Bu-Tian, Jung, Audrey Y., Karlan, Beth Y., Kellar, Melissa, Kiemeney, Lambertus A., Kiong Lim, Boon, Kjaer, Susanne K., Krakstad, Camilla, Kupryjanczyk, Jolanta, Lambrechts, Diether, Lambrechts, Sandrina, Le, Nhu D., Lele, Shashi, Lester, Jenny, Levine, Douglas A., Li, Zheng, Liang, Dong, Lissowska, Jolanta, Lu, Karen, Lubinski, Jan, Lundvall, Lene, Massuger, Leon F. A. G., Matsuo, Keitaro, McGuire, Valerie, McLaughlin, John R., McNeish, Iain, Menon, Usha, Milne, Roger L., Modugno, Francesmary, Moysich, Kirsten B., Ness, Roberta B., Nevanlinna, Heli, Odunsi, Kunle, Olson, Sara H., Orlow, Irene, Orsulic, Sandra, Paul, James, Pejovic, Tanja, Pelttari, Liisa M., Permuth, Jenny B., Pike, Malcolm C., Poole, Elizabeth M., Rosen, Barry, Rossing, Mary Anne, Rothstein, Joseph H., Runnebaum, Ingo B., Rzepecka, Iwona K., Schernhammer, Eva, Schwaab, Ira, Shu, Xiao-Ou, Shvetsov, Yurii B., Siddiqui, Nadeem, Sieh, Weiva, Song, Honglin, Southey, Melissa C., Spiewankiewicz, Beata, Sucheston-Campbell, Lara, Tangen, Ingvild L., Teo, Soo-Hwang, Terry, Kathryn L., Thompson, Pamela J., Thomsen, Lotte, Tworoger, Shelley S., van Altena, Anne M., Vergote, Ignace, Vestrheim Thomsen, Liv Cecilie, Vierkant, Robert A., Walsh, Christine S., Wang-Gohrke, Shan, Wentzensen, Nicolas, Whittemore, Alice S., Wicklund, Kristine G., Wilkens, Lynne R., Woo, Yin-Ling, Wu, Anna H., Wu, Xifeng, Xiang, Yong-Bing, Yang, Hannah, Zheng, Wei, Ziogas, Argyrios, Lee, Alice W, Pearce, Celeste L., Berchuck, Andrew, Schildkraut, Joellen M., Ramus, Susan J., Monteiro, Alvaro N. A., Narod, Steven A., Sellers, Thomas A., Gayther, Simon A., Kelemen, Linda E., Chenevix-Trench, Georgia, Risch, Harvey A., Pharoah, Paul D. P., Goode, Ellen L., Phelan, Catherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034790/
https://www.ncbi.nlm.nih.gov/pubmed/29979793
http://dx.doi.org/10.1371/journal.pone.0197561