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Synergistic assembly of human pre-spliceosomes across introns and exons

Most human genes contain multiple introns, necessitating mechanisms to effectively define exons and ensure their proper connection by spliceosomes. Human spliceosome assembly involves both cross-intron and cross-exon interactions, but how these work together is unclear. We examined in human nuclear...

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Detalles Bibliográficos
Autores principales: Braun, Joerg E, Friedman, Larry J, Gelles, Jeff, Moore, Melissa J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035042/
https://www.ncbi.nlm.nih.gov/pubmed/29932423
http://dx.doi.org/10.7554/eLife.37751