Loss of heterozygosity as a marker of homologous repair deficiency in multiple myeloma: a role for PARP inhibition?

PARP inhibitors can induce synthetic lethality in tumors characterized by homologous recombination deficiency (HRD), which can be detected by evaluating genome-wide loss of heterozygosity (LOH). Multiple myeloma (MM) is a genetically unstable tumor and we hypothesized that HRD-related LOH (HRD-LOH)...

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Detalles Bibliográficos
Autores principales: Pawlyn, Charlotte, Loehr, Andrea, Ashby, Cody, Tytarenko, Ruslana, Deshpande, Shayu, Sun, James, Fedorchak, Kyle, Mughal, Tariq, Davies, Faith E., Walker, Brian A., Morgan, Gareth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035152/
https://www.ncbi.nlm.nih.gov/pubmed/29467487
http://dx.doi.org/10.1038/s41375-018-0017-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035152/
https://www.ncbi.nlm.nih.gov/pubmed/29467487
http://dx.doi.org/10.1038/s41375-018-0017-0

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