ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma

Recurrent mutations are frequently associated with transcription factor (TF) binding sites (TFBS) in melanoma, but the mechanism driving mutagenesis at TFBS is unclear. Here, we use a method called CPD-seq to map the distribution of UV-induced cyclobutane pyrimidine dimers (CPDs) across the human ge...

Descripción completa

Detalles Bibliográficos
Autores principales: Mao, Peng, Brown, Alexander J., Esaki, Shingo, Lockwood, Svetlana, Poon, Gregory M. K., Smerdon, Michael J., Roberts, Steven A., Wyrick, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035183/
https://www.ncbi.nlm.nih.gov/pubmed/29980679
http://dx.doi.org/10.1038/s41467-018-05064-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035183/
https://www.ncbi.nlm.nih.gov/pubmed/29980679
http://dx.doi.org/10.1038/s41467-018-05064-0

Ejemplares similares