Understanding the indirect DNA read-out specificity of I-CreI Meganuclease

The high DNA specificity of homing endonucleases makes them a powerful protein scaffold to engineer enzymes for genome manipulation. Understanding their molecular recognition of DNA is an important prerequisite to generate engineered enzymes able to cleave DNA in specific desired genome sites. Prote...

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Detalles Bibliográficos
Autores principales: Prieto, Jesús, Redondo, Pilar, López-Méndez, Blanca, D’Abramo, Marco, Merino, Nekane, Blanco, Francisco J., Duchateau, Phillipe, Montoya, Guillermo, Molina, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035192/
https://www.ncbi.nlm.nih.gov/pubmed/29980759
http://dx.doi.org/10.1038/s41598-018-28599-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035192/
https://www.ncbi.nlm.nih.gov/pubmed/29980759
http://dx.doi.org/10.1038/s41598-018-28599-0

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