Spinal PKCα inhibition and gene-silencing for pain relief: AMPAR trafficking at the synapses between primary afferents and sensory interneurons

Upregulation of Ca(2+)-permeable AMPA receptors (CP-AMPARs) in dorsal horn (DH) neurons has been causally linked to persistent inflammatory pain. This upregulation, demonstrated for both synaptic and extrasynaptic AMPARs, depends on the protein kinase C alpha (PKCα) activation; hence, spinal PKC inh...

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Detalles Bibliográficos
Autores principales: Kopach, Olga, Krotov, Volodymyr, Shysh, Angela, Sotnic, Andrij, Viatchenko-Karpinski, Viacheslav, Dosenko, Victor, Voitenko, Nana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035211/
https://www.ncbi.nlm.nih.gov/pubmed/29980697
http://dx.doi.org/10.1038/s41598-018-28512-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035211/
https://www.ncbi.nlm.nih.gov/pubmed/29980697
http://dx.doi.org/10.1038/s41598-018-28512-9

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