Cargando…
Spinal PKCα inhibition and gene-silencing for pain relief: AMPAR trafficking at the synapses between primary afferents and sensory interneurons
Upregulation of Ca(2+)-permeable AMPA receptors (CP-AMPARs) in dorsal horn (DH) neurons has been causally linked to persistent inflammatory pain. This upregulation, demonstrated for both synaptic and extrasynaptic AMPARs, depends on the protein kinase C alpha (PKCα) activation; hence, spinal PKC inh...
Autores principales: | Kopach, Olga, Krotov, Volodymyr, Shysh, Angela, Sotnic, Andrij, Viatchenko-Karpinski, Viacheslav, Dosenko, Victor, Voitenko, Nana |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035211/ https://www.ncbi.nlm.nih.gov/pubmed/29980697 http://dx.doi.org/10.1038/s41598-018-28512-9 |
Ejemplares similares
-
Development of inflammation-induced hyperalgesia and allodynia is associated with the upregulation of extrasynaptic AMPA receptors in tonically firing lamina II dorsal horn neurons
por: Kopach, Olga, et al.
Publicado: (2012) -
Opposite, bidirectional shifts in excitation and inhibition in specific types of dorsal horn interneurons are associated with spasticity and pain post-SCI
por: Kopach, Olga, et al.
Publicado: (2017) -
Inhibition of Spinal Ca(2+)-Permeable AMPA Receptors with Dicationic Compounds Alleviates Persistent Inflammatory Pain without Adverse Effects
por: Kopach, Olga, et al.
Publicado: (2016) -
Elucidating afferent-driven presynaptic inhibition of primary afferent input to spinal laminae I and X
por: Krotov, Volodymyr, et al.
Publicado: (2023) -
Segmental and descending control of primary afferent input to the spinal lamina X
por: Krotov, Volodymyr, et al.
Publicado: (2022)