Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease

BACKGROUND: Prostate cancer (PrCa) demonstrates a heterogeneous clinical presentation ranging from largely indolent to lethal. We sought to identify a signature of rare inherited variants that distinguishes between these two extreme phenotypes. METHODS: We sequenced germline whole exomes from 139 ag...

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Detalles Bibliográficos
Autores principales: Mijuskovic, Martina, Saunders, Edward J., Leongamornlert, Daniel A., Wakerell, Sarah, Whitmore, Ian, Dadaev, Tokhir, Cieza-Borrella, Clara, Govindasami, Koveela, Brook, Mark N., Haiman, Christopher A., Conti, David V., Eeles, Rosalind A., Kote-Jarai, Zsofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035259/
https://www.ncbi.nlm.nih.gov/pubmed/29915322
http://dx.doi.org/10.1038/s41416-018-0141-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035259/
https://www.ncbi.nlm.nih.gov/pubmed/29915322
http://dx.doi.org/10.1038/s41416-018-0141-7

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