Cargando…

Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease

BACKGROUND: Prostate cancer (PrCa) demonstrates a heterogeneous clinical presentation ranging from largely indolent to lethal. We sought to identify a signature of rare inherited variants that distinguishes between these two extreme phenotypes. METHODS: We sequenced germline whole exomes from 139 ag...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mijuskovic, Martina, Saunders, Edward J., Leongamornlert, Daniel A., Wakerell, Sarah, Whitmore, Ian, Dadaev, Tokhir, Cieza-Borrella, Clara, Govindasami, Koveela, Brook, Mark N., Haiman, Christopher A., Conti, David V., Eeles, Rosalind A., Kote-Jarai, Zsofia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035259/ https://www.ncbi.nlm.nih.gov/pubmed/29915322 http://dx.doi.org/10.1038/s41416-018-0141-7

Ejemplares similares

Correction: Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease
por: Mijuskovic, Martina, et al.
Publicado: (2019)

Germline DNA Repair Gene Mutations in Young-onset Prostate Cancer Cases in the UK: Evidence for a More Extensive Genetic Panel
por: Leongamornlert, Daniel A., et al.
Publicado: (2019)

LocusExplorer: a user-friendly tool for integrated visualization of human genetic association data and biological annotations
por: Dadaev, Tokhir, et al.
Publicado: (2016)

Germline genetic variation in prostate susceptibility does not predict outcomes in the chemoprevention trials PCPT and SELECT
por: Ahmed, Mahbubl, et al.
Publicado: (2019)

Relationship of self-reported body size and shape with risk for prostate cancer: A UK case-control study
por: Aladwani, Mohammad, et al.
Publicado: (2020)

Prostate cancer risk in men of differing genetic ancestry and approaches to disease screening and management in these groups
por: McHugh, Jana, et al.
Publicado: (2021)

Identification of Germline Genetic Variants that Increase Prostate Cancer Risk and Influence Development of Aggressive Disease
por: Saunders, Edward J., et al.
Publicado: (2021)

Homeobox B13 G84E Mutation and Prostate Cancer Risk
por: Nyberg, Tommy, et al.
Publicado: (2019)

Germline BRCA1 mutations increase prostate cancer risk
por: Leongamornlert, D, et al.
Publicado: (2012)

CanRisk-Prostate: A Comprehensive, Externally Validated Risk Model for the Prediction of Future Prostate Cancer
por: Nyberg, Tommy, et al.
Publicado: (2023)

Serum testosterone and prostate cancer in men with germline BRCA1/2 pathogenic variants
por: Dias, Alexander, et al.
Publicado: (2023)

Frequent germline deleterious mutations in DNA repair genes in familial prostate cancer cases are associated with advanced disease
por: Leongamornlert, D, et al.
Publicado: (2014)

Telomere Length Shows No Association with BRCA1 and BRCA2 Mutation Status
por: Killick, Emma, et al.
Publicado: (2014)

Impact of germline DNA repair gene variants on prognosis and treatment of men with advanced prostate cancer
por: Hansen, Emma B., et al.
Publicado: (2023)

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array
por: Saunders, Edward J, et al.
Publicado: (2018)

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array
por: Saunders, Edward J, et al.
Publicado: (2016)

Rare Germline Variants in ATM Predispose to Prostate Cancer: A PRACTICAL Consortium Study
por: Karlsson, Questa, et al.
Publicado: (2021)

Author Correction: Large-scale transcriptome-wide association study identifies new prostate cancer risk regions
por: Mancuso, Nicholas, et al.
Publicado: (2019)

Large-scale transcriptome-wide association study identifies new prostate cancer risk regions
por: Mancuso, Nicholas, et al.
Publicado: (2018)

The PROFILE Feasibility Study: Targeted Screening of Men With a Family History of Prostate Cancer
por: Castro, Elena, et al.
Publicado: (2016)

BRCA2 is a moderate penetrance gene contributing to young-onset prostate cancer: implications for genetic testing in prostate cancer patients
por: Kote-Jarai, Z, et al.
Publicado: (2011)

Common genetic variants associated with disease from genome-wide association studies are mutually exclusive in prostate cancer and rheumatoid arthritis
por: Orozco, Gisela, et al.
Publicado: (2013)

The BARCODE1 Pilot: a feasibility study of using germline single nucleotide polymorphisms to target prostate cancer screening
por: Benafif, Sarah, et al.
Publicado: (2021)

BRCA1, BRCA2 and their possible function in DNA damage response
por: Kote-Jarai, Z, et al.
Publicado: (1999)

A recurrent truncating germline mutation in the BRIP1/FANCJ gene and susceptibility to prostate cancer
por: Kote-Jarai, Z, et al.
Publicado: (2009)

Germline variation at 8q24 and prostate cancer risk in men of European ancestry
por: Matejcic, Marco, et al.
Publicado: (2018)

Gene promoter hypermethylation in ductal lavage fluid from healthy BRCA gene mutation carriers and mutation-negative controls
por: Locke, Imogen, et al.
Publicado: (2007)

Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry
por: Matejcic, Marco, et al.
Publicado: (2019)

Diffusion-weighted MRI for detecting prostate tumour in men at increased genetic risk
por: deSouza, Nandita M., et al.
Publicado: (2014)

Polygenic risk-tailored screening for prostate cancer: A benefit–harm and cost-effectiveness modelling study
por: Callender, Tom, et al.
Publicado: (2019)

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans
por: Amin Al Olama, Ali, et al.
Publicado: (2015)

Germline genetic profiling in prostate cancer: latest developments and potential clinical applications
por: Ahmed, Mahbubl, et al.
Publicado: (2015)

Ancestry-specific predisposing germline variants in cancer
por: Oak, Ninad, et al.
Publicado: (2020)

Comprehensive Functional Annotation of 77 Prostate Cancer Risk Loci
por: Hazelett, Dennis J., et al.
Publicado: (2014)

Germline BAP1 mutations predispose to malignant mesothelioma
por: Testa, Joseph R., et al.
Publicado: (2011)

Functional Analysis Identifies Damaging CHEK2 Missense Variants Associated with Increased Cancer Risk
por: Boonen, Rick A.C.M., et al.
Publicado: (2022)

Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects
por: Ito, Shuji, et al.
Publicado: (2023)

Germline mutations in BAP1 predispose to melanocytic tumors
por: Wiesner, Thomas, et al.
Publicado: (2011)

Germline GPR161 Mutations Predispose to Pediatric Medulloblastoma
por: Begemann, Matthias, et al.
Publicado: (2020)

Glutathione-S-transferase M1, T1 and P1 polymorphisms, and breast cancer risk, in BRCA1/2 mutation carriers
por: Kadouri, L, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_no28usgmi9l12fulgj4nbpm5hn