Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis

DNA ligase IV (LigIV) performs the final DNA nick-sealing step of classical nonhomologous end-joining, which is critical for immunoglobulin gene maturation and efficient repair of genotoxic DNA double-strand breaks. Hypomorphic LigIV mutations cause extreme radiation sensitivity and immunodeficiency...

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Detalles Bibliográficos
Autores principales: Kaminski, Andrea M., Tumbale, Percy P., Schellenberg, Matthew J., Williams, R. Scott, Williams, Jason G., Kunkel, Thomas A., Pedersen, Lars C., Bebenek, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035275/
https://www.ncbi.nlm.nih.gov/pubmed/29980672
http://dx.doi.org/10.1038/s41467-018-05024-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035275/
https://www.ncbi.nlm.nih.gov/pubmed/29980672
http://dx.doi.org/10.1038/s41467-018-05024-8

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