Increased sensitivity to apoptosis upon endoplasmic reticulum stress-induced activation of the unfolded protein response in chemotherapy-resistant malignant pleural mesothelioma

BACKGROUND: Standard treatment for advanced malignant pleural mesothelioma (MPM) is a cisplatin/pemetrexed (MTA) regimen; however, this is confronted by drug resistance. Proteotoxic stress in the endoplasmic reticulum (ER) is a hallmark of cancer and some rely on this stress signalling in response t...

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Detalles Bibliográficos
Autores principales: Xu, Duo, Liang, Shun-Qing, Yang, Haitang, Lüthi, Ursina, Riether, Carsten, Berezowska, Sabina, Marti, Thomas M., Hall, Sean R. R., Bruggmann, Rémy, Kocher, Gregor J., Schmid, Ralph A., Peng, Ren-Wang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035279/
https://www.ncbi.nlm.nih.gov/pubmed/29921948
http://dx.doi.org/10.1038/s41416-018-0145-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035279/
https://www.ncbi.nlm.nih.gov/pubmed/29921948
http://dx.doi.org/10.1038/s41416-018-0145-3

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