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Increased sensitivity to apoptosis upon endoplasmic reticulum stress-induced activation of the unfolded protein response in chemotherapy-resistant malignant pleural mesothelioma

BACKGROUND: Standard treatment for advanced malignant pleural mesothelioma (MPM) is a cisplatin/pemetrexed (MTA) regimen; however, this is confronted by drug resistance. Proteotoxic stress in the endoplasmic reticulum (ER) is a hallmark of cancer and some rely on this stress signalling in response t...

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Detalles Bibliográficos
Autores principales:	Xu, Duo, Liang, Shun-Qing, Yang, Haitang, Lüthi, Ursina, Riether, Carsten, Berezowska, Sabina, Marti, Thomas M., Hall, Sean R. R., Bruggmann, Rémy, Kocher, Gregor J., Schmid, Ralph A., Peng, Ren-Wang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035279/ https://www.ncbi.nlm.nih.gov/pubmed/29921948 http://dx.doi.org/10.1038/s41416-018-0145-3

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