The effect of ERCC1 and ERCC2 gene polymorphysims on response to cisplatin based therapy in osteosarcoma patients

BACKGROUND: Cisplatin is one of the major drugs that used in the treatment of osteosarcoma. Cisplatin exerts its function by making cisplatin-DNA adducts culminating in cellular death. These adducts found to be repaired by nucleotide excision repair (NER) pathway. This study aimed to evaluate if pol...

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Detalles Bibliográficos
Autores principales: Obiedat, Hadeel, Alrabadi, Nasr, Sultan, Eyad, Al Shatti, Marwa, Zihlif, Malek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035436/
https://www.ncbi.nlm.nih.gov/pubmed/29980176
http://dx.doi.org/10.1186/s12881-018-0627-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035436/
https://www.ncbi.nlm.nih.gov/pubmed/29980176
http://dx.doi.org/10.1186/s12881-018-0627-4

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