Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering

Elucidating the rules for receptor triggering in cell-cell and cell-matrix contacts requires precise control of ligand positioning in three dimensions. Here, we use the T cell receptor (TCR) as a model and subject T cells to different geometric arrangements of ligands, using a nanofabricated single-...

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Detalles Bibliográficos
Autores principales: Cai, Haogang, Muller, James, Depoil, David, Mayya, Viveka, Sheetz, Michael P., Dustin, Michael L., Wind, Shalom J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035778/
https://www.ncbi.nlm.nih.gov/pubmed/29713075
http://dx.doi.org/10.1038/s41565-018-0113-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035778/
https://www.ncbi.nlm.nih.gov/pubmed/29713075
http://dx.doi.org/10.1038/s41565-018-0113-3

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