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Trehalose inhibits H(2)O(2)-induced autophagic death in dopaminergic SH-SY5Y cells via mitigation of ROS-dependent endoplasmic reticulum stress and AMPK activation

Autophagy is a catabolic process to maintain intracellular homeostasis via removal of cytoplasmic macromolecules and damaged cellular organelles through lysosome-mediated degradation. Trehalose is often regarded as an autophagy inducer, but we reported previously that it could prevent ischemic insul...

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Detalles Bibliográficos
Autores principales: Gao, Zhijie, Wang, Helei, Zhang, Bo, Wu, Xuemei, Zhang, Yanfeng, Ge, Pengfei, Chi, Guangfan, Liang, Jianmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036158/
https://www.ncbi.nlm.nih.gov/pubmed/30013443
http://dx.doi.org/10.7150/ijms.25656