Hypertrophic cardiomyopathy mutations increase myofilament Ca(2+) buffering, alter intracellular Ca(2+) handling, and stimulate Ca(2+)-dependent signaling

Mutations in thin filament regulatory proteins that cause hypertrophic cardiomyopathy (HCM) increase myofilament Ca(2+) sensitivity. Mouse models exhibit increased Ca(2+) buffering and arrhythmias, and we hypothesized that these changes are primary effects of the mutations (independent of compensato...

Descripción completa

Detalles Bibliográficos
Autores principales: Robinson, Paul, Liu, Xing, Sparrow, Alexander, Patel, Suketu, Zhang, Yin-Hua, Casadei, Barbara, Watkins, Hugh, Redwood, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036197/
https://www.ncbi.nlm.nih.gov/pubmed/29760186
http://dx.doi.org/10.1074/jbc.RA118.002081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036197/
https://www.ncbi.nlm.nih.gov/pubmed/29760186
http://dx.doi.org/10.1074/jbc.RA118.002081

Ejemplares similares