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Hypertrophic cardiomyopathy mutations increase myofilament Ca(2+) buffering, alter intracellular Ca(2+) handling, and stimulate Ca(2+)-dependent signaling

Mutations in thin filament regulatory proteins that cause hypertrophic cardiomyopathy (HCM) increase myofilament Ca(2+) sensitivity. Mouse models exhibit increased Ca(2+) buffering and arrhythmias, and we hypothesized that these changes are primary effects of the mutations (independent of compensato...

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Detalles Bibliográficos
Autores principales:	Robinson, Paul, Liu, Xing, Sparrow, Alexander, Patel, Suketu, Zhang, Yin-Hua, Casadei, Barbara, Watkins, Hugh, Redwood, Charles
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036197/ https://www.ncbi.nlm.nih.gov/pubmed/29760186 http://dx.doi.org/10.1074/jbc.RA118.002081

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