Formation of the Intrathymic Dendritic Cell Pool Requires CCL21-Mediated Recruitment of CCR7(+) Progenitors to the Thymus

During αβ T cell development in the thymus, migration of newly selected CD4(+) and CD8(+) thymocytes into medullary areas enables tolerance mechanisms to purge the newly selected αβ TCR repertoire of autoreactive specificities. Thymic dendritic cells (DC) play key roles in this process and consist o...

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Detalles Bibliográficos
Autores principales: Cosway, Emilie J., Ohigashi, Izumi, Schauble, Karin, Parnell, Sonia M., Jenkinson, William E., Luther, Sanjiv, Takahama, Yousuke, Anderson, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2018
Materias:
Immune System Development
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036229/
https://www.ncbi.nlm.nih.gov/pubmed/29784760
http://dx.doi.org/10.4049/jimmunol.1800348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036229/
https://www.ncbi.nlm.nih.gov/pubmed/29784760
http://dx.doi.org/10.4049/jimmunol.1800348

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