Atorvastatin Inhibits the HIF1α-PPAR Axis, Which Is Essential for Maintaining the Function of Human Induced Pluripotent Stem Cells

We herein report a novel mechanism of action of statin preparations using a new drug discovery method. Milk fat globule-EGF factor 8 protein (MFG-E8) was identified from the secretory component of mouse embryonic fibroblast (MEF) as a cell adhesion-promoting factor effective for screening active cel...

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Detalles Bibliográficos
Autores principales: Nakashima, Yoshiki, Miyagi-Shiohira, Chika, Noguchi, Hirofumi, Omasa, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036234/
https://www.ncbi.nlm.nih.gov/pubmed/29929789
http://dx.doi.org/10.1016/j.ymthe.2018.06.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036234/
https://www.ncbi.nlm.nih.gov/pubmed/29929789
http://dx.doi.org/10.1016/j.ymthe.2018.06.005

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