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Characterizing the effect of expression of an acetyl-CoA synthetase insensitive to acetylation on co-utilization of glucose and acetate in batch and continuous cultures of E. coli W

BACKGROUND: Due to its high stress tolerance and low acetate secretion, Escherichia coli W is reported to be a good production host for several metabolites and recombinant proteins. However, simultaneous co-utilization of glucose and other substrates such as acetate remains a challenge. The activity...

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Detalles Bibliográficos
Autores principales: Novak, Katharina, Flöckner, Lukas, Erian, Anna Maria, Freitag, Philipp, Herwig, Christoph, Pflügl, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036698/
https://www.ncbi.nlm.nih.gov/pubmed/29986728
http://dx.doi.org/10.1186/s12934-018-0955-2