Visible light-mediated difluoroalkylation of electron-deficient alkenes

A method for the reductive difluoroalkylation of electron-deficient alkenes using 1,1-difluorinated iodides mediated by irradiation with blue light is described. The reaction involves radical addition of 1,1-difluorinated radicals at the double bond followed by hydrogen atom transfer from sodium cya...

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Detalles Bibliográficos
Autores principales: Supranovich, Vyacheslav I, Levin, Vitalij V, Struchkova, Marina I, Hu, Jinbo, Dilman, Alexander D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2018
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036985/
https://www.ncbi.nlm.nih.gov/pubmed/30013689
http://dx.doi.org/10.3762/bjoc.14.139
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author Supranovich, Vyacheslav I
Levin, Vitalij V
Struchkova, Marina I
Hu, Jinbo
Dilman, Alexander D
author_facet Supranovich, Vyacheslav I
Levin, Vitalij V
Struchkova, Marina I
Hu, Jinbo
Dilman, Alexander D
author_sort Supranovich, Vyacheslav I
collection PubMed
description A method for the reductive difluoroalkylation of electron-deficient alkenes using 1,1-difluorinated iodides mediated by irradiation with blue light is described. The reaction involves radical addition of 1,1-difluorinated radicals at the double bond followed by hydrogen atom transfer from sodium cyanoborohydride.
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spelling pubmed-60369852018-07-16 Visible light-mediated difluoroalkylation of electron-deficient alkenes Supranovich, Vyacheslav I Levin, Vitalij V Struchkova, Marina I Hu, Jinbo Dilman, Alexander D Beilstein J Org Chem Letter A method for the reductive difluoroalkylation of electron-deficient alkenes using 1,1-difluorinated iodides mediated by irradiation with blue light is described. The reaction involves radical addition of 1,1-difluorinated radicals at the double bond followed by hydrogen atom transfer from sodium cyanoborohydride. Beilstein-Institut 2018-07-02 /pmc/articles/PMC6036985/ /pubmed/30013689 http://dx.doi.org/10.3762/bjoc.14.139 Text en Copyright © 2018, Supranovich et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Supranovich, Vyacheslav I
Levin, Vitalij V
Struchkova, Marina I
Hu, Jinbo
Dilman, Alexander D
Visible light-mediated difluoroalkylation of electron-deficient alkenes
title Visible light-mediated difluoroalkylation of electron-deficient alkenes
title_full Visible light-mediated difluoroalkylation of electron-deficient alkenes
title_fullStr Visible light-mediated difluoroalkylation of electron-deficient alkenes
title_full_unstemmed Visible light-mediated difluoroalkylation of electron-deficient alkenes
title_short Visible light-mediated difluoroalkylation of electron-deficient alkenes
title_sort visible light-mediated difluoroalkylation of electron-deficient alkenes
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036985/
https://www.ncbi.nlm.nih.gov/pubmed/30013689
http://dx.doi.org/10.3762/bjoc.14.139
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