Drug targeting to decrease cardiotoxicity – determination of the cytotoxic effect of GnRH-based conjugates containing doxorubicin, daunorubicin and methotrexate on human cardiomyocytes and endothelial cells

Background: Cardiomyopathy induced by the chemotherapeutic agents doxorubicin and daunorubicin is a major limiting factor for their application in cancer therapy. Chemotactic drug targeting potentially increases the tumor selectivity of drugs and decreases their cardiotoxicity. Increased expression...

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Detalles Bibliográficos
Autores principales: Polgár, Livia, Lajkó, Eszter, Soós, Pál, Láng, Orsolya, Manea, Marilena, Merkely, Béla, Mező, Gábor, Kőhidai, László
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2018
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Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037002/
https://www.ncbi.nlm.nih.gov/pubmed/30013686
http://dx.doi.org/10.3762/bjoc.14.136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037002/
https://www.ncbi.nlm.nih.gov/pubmed/30013686
http://dx.doi.org/10.3762/bjoc.14.136

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