Phosphorylation of IRS4 by CK1γ2 promotes its degradation by CHIP through the ubiquitin/lysosome pathway

IRS4, a member of the insulin receptor substrate protein family, can induce constitutive PI3K/AKT hyperactivation and cell proliferation even in the absence of insulin or growth factors and promote tumorigenesis, but its regulation has only been explored at the transcriptional level. Methods: Scansi...

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Detalles Bibliográficos
Autores principales: Li, Xinchun, Zhong, Li, Wang, Zhuo, Chen, Huiming, Liao, Dan, Zhang, Ruhua, Zhang, Hongyu, Kang, Tiebang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037025/
https://www.ncbi.nlm.nih.gov/pubmed/30026872
http://dx.doi.org/10.7150/thno.26021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037025/
https://www.ncbi.nlm.nih.gov/pubmed/30026872
http://dx.doi.org/10.7150/thno.26021

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