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Enzyme Architecture: Amino Acid Side-Chains That Function To Optimize the Basicity of the Active Site Glutamate of Triosephosphate Isomerase
[Image: see text] We report pH rate profiles for k(cat) and K(m) for the isomerization reaction of glyceraldehyde 3-phosphate catalyzed by wildtype triosephosphate isomerase (TIM) from three organisms and by ten mutants of TIM; and, for K(i) for inhibition of this reaction by phosphoglycolate triani...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037162/ https://www.ncbi.nlm.nih.gov/pubmed/29862813 http://dx.doi.org/10.1021/jacs.8b04367 |