Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis

Alterations in microRNA (miRNA) processing have been previously linked to aging. Here we used the small molecule enoxacin to pharmacologically interfere with miRNA biogenesis and study how it affects aging in C. elegans. Enoxacin extended worm lifespan and promoted survival under normal and oxidativ...

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Detalles Bibliográficos
Autores principales: Pinto, Silas, Sato, Vitor N., De-Souza, Evandro A., Ferraz, Rafael C., Camara, Henrique, Pinca, Ana Paula F., Mazzotti, Diego R., Lovci, Michael T., Tonon, Guilherme, Lopes-Ramos, Camila M., Parmigiani, Raphael B., Wurtele, Martin, Massirer, Katlin B., Mori, Marcelo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037660/
https://www.ncbi.nlm.nih.gov/pubmed/29986212
http://dx.doi.org/10.1016/j.redox.2018.06.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037660/
https://www.ncbi.nlm.nih.gov/pubmed/29986212
http://dx.doi.org/10.1016/j.redox.2018.06.006

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