Structural and functional characterization of suramin-bound MjTX-I from Bothrops moojeni suggests a particular myotoxic mechanism

Local myonecrosis is the main event resulting from snakebite envenomation by the Bothrops genus and, frequently, it is not efficiently neutralized by antivenom administration. Proteases, phospholipases A(2) (PLA(2)) and PLA(2)-like toxins are found in venom related to muscle damage. Functional sites...

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Detalles Bibliográficos
Autores principales: Salvador, Guilherme H. M., Dreyer, Thiago R., Gomes, Antoniel A. S., Cavalcante, Walter L. G., dos Santos, Juliana I., Gandin, César A., de Oliveira Neto, Mário, Gallacci, Márcia, Fontes, Marcos R. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037679/
https://www.ncbi.nlm.nih.gov/pubmed/29985425
http://dx.doi.org/10.1038/s41598-018-28584-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037679/
https://www.ncbi.nlm.nih.gov/pubmed/29985425
http://dx.doi.org/10.1038/s41598-018-28584-7

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