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Preservation of explicit learning of visuomotor sequences during Parkinson’s disease progression

While motor learning approaches are effective in rehabilitating Parkinson’s disease (PD) patients, many studies reported deficits in sequential motor learning in these patients. We hypothesised that preserved explicit learning of visuomotor sequences in PD patients contributed to the effectiveness o...

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Autores principales: Kitahara, Eriko, Shimo, Yasushi, Mori, Hideo, Nagaoka, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037724/
https://www.ncbi.nlm.nih.gov/pubmed/29985436
http://dx.doi.org/10.1038/s41598-018-28640-2
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author Kitahara, Eriko
Shimo, Yasushi
Mori, Hideo
Nagaoka, Masanori
author_facet Kitahara, Eriko
Shimo, Yasushi
Mori, Hideo
Nagaoka, Masanori
author_sort Kitahara, Eriko
collection PubMed
description While motor learning approaches are effective in rehabilitating Parkinson’s disease (PD) patients, many studies reported deficits in sequential motor learning in these patients. We hypothesised that preserved explicit learning of visuomotor sequences in PD patients contributed to the effectiveness of motor learning approaches. However, there are very few studies analysing explicit learning of visuomotor sequences during the progression of PD. We investigated this phenomenon in 23 patients with moderate to severe PD (Hoehn–Yahr stages II-IV) and 17 age-matched controls using sequential button-press tasks (2 × 5 task). We found (1) no significant differences in numbers of errors in the 2 × 5 task among control and PD groups. (2) There was a significant difference in response times while exploring correct sequences (ERT) among control and PD groups; ERTs in stage-IV patients tended to be longer than those of control and stage-II groups. (3) All four groups significantly improved their performance (i.e., reduced ERTs in the 2 × 5 task) with sequence repetition, although stage-III:IV patients were slower. Thus, even patients with severe PD can learn visual sequences and can translate them into visuomotor sequences (explicit visuomotor sequence learning), albeit slower than controls, providing evidence for effective motor learning approaches during rehabilitation of patients with advanced PD.
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spelling pubmed-60377242018-07-12 Preservation of explicit learning of visuomotor sequences during Parkinson’s disease progression Kitahara, Eriko Shimo, Yasushi Mori, Hideo Nagaoka, Masanori Sci Rep Article While motor learning approaches are effective in rehabilitating Parkinson’s disease (PD) patients, many studies reported deficits in sequential motor learning in these patients. We hypothesised that preserved explicit learning of visuomotor sequences in PD patients contributed to the effectiveness of motor learning approaches. However, there are very few studies analysing explicit learning of visuomotor sequences during the progression of PD. We investigated this phenomenon in 23 patients with moderate to severe PD (Hoehn–Yahr stages II-IV) and 17 age-matched controls using sequential button-press tasks (2 × 5 task). We found (1) no significant differences in numbers of errors in the 2 × 5 task among control and PD groups. (2) There was a significant difference in response times while exploring correct sequences (ERT) among control and PD groups; ERTs in stage-IV patients tended to be longer than those of control and stage-II groups. (3) All four groups significantly improved their performance (i.e., reduced ERTs in the 2 × 5 task) with sequence repetition, although stage-III:IV patients were slower. Thus, even patients with severe PD can learn visual sequences and can translate them into visuomotor sequences (explicit visuomotor sequence learning), albeit slower than controls, providing evidence for effective motor learning approaches during rehabilitation of patients with advanced PD. Nature Publishing Group UK 2018-07-09 /pmc/articles/PMC6037724/ /pubmed/29985436 http://dx.doi.org/10.1038/s41598-018-28640-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kitahara, Eriko
Shimo, Yasushi
Mori, Hideo
Nagaoka, Masanori
Preservation of explicit learning of visuomotor sequences during Parkinson’s disease progression
title Preservation of explicit learning of visuomotor sequences during Parkinson’s disease progression
title_full Preservation of explicit learning of visuomotor sequences during Parkinson’s disease progression
title_fullStr Preservation of explicit learning of visuomotor sequences during Parkinson’s disease progression
title_full_unstemmed Preservation of explicit learning of visuomotor sequences during Parkinson’s disease progression
title_short Preservation of explicit learning of visuomotor sequences during Parkinson’s disease progression
title_sort preservation of explicit learning of visuomotor sequences during parkinson’s disease progression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037724/
https://www.ncbi.nlm.nih.gov/pubmed/29985436
http://dx.doi.org/10.1038/s41598-018-28640-2
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