Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia

Stem cell memory T (T(SCM)) and central memory T (T(CM)) cells can rapidly differentiate into effector memory (T(EM)) and terminal effector (T(EF)) T cells, and have the most potential for immunotherapy. In this study, we found that the frequency of T(SCM) and T(CM) cells in the CD8+ population dram...

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Autores principales: Xu, Ling, Yao, Danlin, Tan, Jiaxiong, He, Zifan, Yu, Zhi, Chen, Jie, Luo, Gengxin, Wang, Chunli, Zhou, Fenfang, Zha, Xianfeng, Chen, Shaohua, Li, Yangqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038290/
https://www.ncbi.nlm.nih.gov/pubmed/29986734
http://dx.doi.org/10.1186/s13045-018-0636-y
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author Xu, Ling
Yao, Danlin
Tan, Jiaxiong
He, Zifan
Yu, Zhi
Chen, Jie
Luo, Gengxin
Wang, Chunli
Zhou, Fenfang
Zha, Xianfeng
Chen, Shaohua
Li, Yangqiu
author_facet Xu, Ling
Yao, Danlin
Tan, Jiaxiong
He, Zifan
Yu, Zhi
Chen, Jie
Luo, Gengxin
Wang, Chunli
Zhou, Fenfang
Zha, Xianfeng
Chen, Shaohua
Li, Yangqiu
author_sort Xu, Ling
collection PubMed
description Stem cell memory T (T(SCM)) and central memory T (T(CM)) cells can rapidly differentiate into effector memory (T(EM)) and terminal effector (T(EF)) T cells, and have the most potential for immunotherapy. In this study, we found that the frequency of T(SCM) and T(CM) cells in the CD8+ population dramatically decreased together with increases in T(EM) and T(EF) cells, particularly in younger patients with acute myeloid leukemia (AML) (< 60 years). These alterations persisted in patients who achieved complete remission after chemotherapy. The decrease in T(SCM) and T(CM) together with the increase in differentiated T(EM) and T(EF) subsets in CD8+ T cells may explain the reduced T cell response and subdued anti-leukemia capacity in AML patients.
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spelling pubmed-60382902018-07-12 Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia Xu, Ling Yao, Danlin Tan, Jiaxiong He, Zifan Yu, Zhi Chen, Jie Luo, Gengxin Wang, Chunli Zhou, Fenfang Zha, Xianfeng Chen, Shaohua Li, Yangqiu J Hematol Oncol Letter to the Editor Stem cell memory T (T(SCM)) and central memory T (T(CM)) cells can rapidly differentiate into effector memory (T(EM)) and terminal effector (T(EF)) T cells, and have the most potential for immunotherapy. In this study, we found that the frequency of T(SCM) and T(CM) cells in the CD8+ population dramatically decreased together with increases in T(EM) and T(EF) cells, particularly in younger patients with acute myeloid leukemia (AML) (< 60 years). These alterations persisted in patients who achieved complete remission after chemotherapy. The decrease in T(SCM) and T(CM) together with the increase in differentiated T(EM) and T(EF) subsets in CD8+ T cells may explain the reduced T cell response and subdued anti-leukemia capacity in AML patients. BioMed Central 2018-07-09 /pmc/articles/PMC6038290/ /pubmed/29986734 http://dx.doi.org/10.1186/s13045-018-0636-y Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Xu, Ling
Yao, Danlin
Tan, Jiaxiong
He, Zifan
Yu, Zhi
Chen, Jie
Luo, Gengxin
Wang, Chunli
Zhou, Fenfang
Zha, Xianfeng
Chen, Shaohua
Li, Yangqiu
Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia
title Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia
title_full Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia
title_fullStr Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia
title_full_unstemmed Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia
title_short Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia
title_sort memory t cells skew toward terminal differentiation in the cd8+ t cell population in patients with acute myeloid leukemia
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038290/
https://www.ncbi.nlm.nih.gov/pubmed/29986734
http://dx.doi.org/10.1186/s13045-018-0636-y
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