Symmetry breaking by enzyme-catalyzed epoxide hydrolysis

Janfalk Carlsson et al. [IUCrJ (2018), 5, 269–282] describe studies on factors determining selective ring opening of methylstyrene oxide stereoisomers by the epoxide hydrolase StEH1. The stereo-differentiating step is selective hydrolysis of an alkylated intermediate formed by reaction of the epoxid...

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Detalles Bibliográficos
Autor principal: Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2018
Materias:
Scientific Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038963/
https://www.ncbi.nlm.nih.gov/pubmed/30002837
http://dx.doi.org/10.1107/S2052252518007005
Descripción
Sumario:Janfalk Carlsson et al. [IUCrJ (2018), 5, 269–282] describe studies on factors determining selective ring opening of methylstyrene oxide stereoisomers by the epoxide hydrolase StEH1. The stereo-differentiating step is selective hydrolysis of an alkylated intermediate formed by reaction of the epoxide with an aspartyl residue.

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