Symmetry breaking by enzyme-catalyzed epoxide hydrolysis

Janfalk Carlsson et al. [IUCrJ (2018), 5, 269–282] describe studies on factors determining selective ring opening of methylstyrene oxide stereoisomers by the epoxide hydrolase StEH1. The stereo-differentiating step is selective hydrolysis of an alkylated intermediate formed by reaction of the epoxid...

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Detalles Bibliográficos
Autor principal: Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2018
Materias:
Scientific Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038963/
https://www.ncbi.nlm.nih.gov/pubmed/30002837
http://dx.doi.org/10.1107/S2052252518007005
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author Schofield, Christopher J.
author_facet Schofield, Christopher J.
author_sort Schofield, Christopher J.
collection PubMed
description Janfalk Carlsson et al. [IUCrJ (2018), 5, 269–282] describe studies on factors determining selective ring opening of methylstyrene oxide stereoisomers by the epoxide hydrolase StEH1. The stereo-differentiating step is selective hydrolysis of an alkylated intermediate formed by reaction of the epoxide with an aspartyl residue.
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spelling pubmed-60389632018-07-12 Symmetry breaking by enzyme-catalyzed epoxide hydrolysis Schofield, Christopher J. IUCrJ Scientific Commentaries Janfalk Carlsson et al. [IUCrJ (2018), 5, 269–282] describe studies on factors determining selective ring opening of methylstyrene oxide stereoisomers by the epoxide hydrolase StEH1. The stereo-differentiating step is selective hydrolysis of an alkylated intermediate formed by reaction of the epoxide with an aspartyl residue. International Union of Crystallography 2018-05-18 /pmc/articles/PMC6038963/ /pubmed/30002837 http://dx.doi.org/10.1107/S2052252518007005 Text en © Christopher J. Schofield 2018 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.http://creativecommons.org/licenses/by/2.0/uk/
spellingShingle Scientific Commentaries
Schofield, Christopher J.
Symmetry breaking by enzyme-catalyzed epoxide hydrolysis
title Symmetry breaking by enzyme-catalyzed epoxide hydrolysis
title_full Symmetry breaking by enzyme-catalyzed epoxide hydrolysis
title_fullStr Symmetry breaking by enzyme-catalyzed epoxide hydrolysis
title_full_unstemmed Symmetry breaking by enzyme-catalyzed epoxide hydrolysis
title_short Symmetry breaking by enzyme-catalyzed epoxide hydrolysis
title_sort symmetry breaking by enzyme-catalyzed epoxide hydrolysis
topic Scientific Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038963/
https://www.ncbi.nlm.nih.gov/pubmed/30002837
http://dx.doi.org/10.1107/S2052252518007005
work_keys_str_mv AT schofieldchristopherj symmetrybreakingbyenzymecatalyzedepoxidehydrolysis

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