BH4-Mediated Enhancement of Endothelial Nitric Oxide Synthase Activity Reduces Hyperoxia-Induced Endothelial Damage and Preserves Vascular Integrity in the Neonate

PURPOSE: Endothelial nitric oxide synthase (eNOS)-derived nitric oxide (NO) has important vasoprotective functions that are compromised in the vasodegenerative phase of retinopathy of prematurity, owing to hyperoxia-induced depletion of the essential NOS cofactor BH4. Because modulating eNOS functio...

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Detalles Bibliográficos
Autores principales: Edgar, Kevin S., Galvin, Orla M., Collins, Anthony, Katusic, Zvonimir S., McDonald, Denise M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2017
Materias:
Retinal Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039076/
https://www.ncbi.nlm.nih.gov/pubmed/28114584
http://dx.doi.org/10.1167/iovs.16-20523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039076/
https://www.ncbi.nlm.nih.gov/pubmed/28114584
http://dx.doi.org/10.1167/iovs.16-20523

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