BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions

The RAS family of proteins is amongst the most highly mutated in human cancers and has so far eluded drug therapy. Currently, much effort is being made to discover mutant RAS inhibitors and in vitro screening for RAS-binding drugs must be followed by cell-based assays. Here, we have developed a robu...

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Detalles Bibliográficos
Autores principales: Bery, Nicolas, Cruz-Migoni, Abimael, Bataille, Carole JR, Quevedo, Camilo E, Tulmin, Hanna, Miller, Ami, Russell, Angela, Phillips, Simon EV, Carr, Stephen B, Rabbitts, Terence H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039175/
https://www.ncbi.nlm.nih.gov/pubmed/29989546
http://dx.doi.org/10.7554/eLife.37122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039175/
https://www.ncbi.nlm.nih.gov/pubmed/29989546
http://dx.doi.org/10.7554/eLife.37122

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