An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

Allostery is an inherent feature of proteins, but it remains challenging to reveal the mechanisms by which allosteric signals propagate. A clearer understanding of this intrinsic circuitry would afford new opportunities to modulate protein function. Here, we have identified allosteric sites in prote...

Descripción completa

Detalles Bibliográficos
Autores principales: Keedy, Daniel A, Hill, Zachary B, Biel, Justin T, Kang, Emily, Rettenmaier, T Justin, Brandão-Neto, José, Pearce, Nicholas M, von Delft, Frank, Wells, James A, Fraser, James S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039181/
https://www.ncbi.nlm.nih.gov/pubmed/29877794
http://dx.doi.org/10.7554/eLife.36307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039181/
https://www.ncbi.nlm.nih.gov/pubmed/29877794
http://dx.doi.org/10.7554/eLife.36307

Ejemplares similares