Fatty Acid Amide Hydrolase Inhibition by JNJ‐42165279: A Multiple‐Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers

Inhibition of fatty acid amide hydrolase (FAAH) potentiates endocannabinoid activity and is hypothesized to have therapeutic potential for mood and anxiety disorders and pain. The clinical profile of JNJ‐42165279, an oral selective FAAH inhibitor, was assessed by investigating the pharmacokinetics,...

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Detalles Bibliográficos
Autores principales: Postnov, Andrey, Schmidt, Mark E., Pemberton, Darrel J., de Hoon, Jan, van Hecken, Anne, van den Boer, Maarten, Zannikos, Peter, van der Ark, Peter, Palmer, James A., Rassnick, Stef, Celen, Sofie, Bormans, Guy, van Laere, Koen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039207/
https://www.ncbi.nlm.nih.gov/pubmed/29575526
http://dx.doi.org/10.1111/cts.12548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039207/
https://www.ncbi.nlm.nih.gov/pubmed/29575526
http://dx.doi.org/10.1111/cts.12548

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