Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

Activation of microglia by classical inflammatory mediators can convert astrocytes to a neurotoxic A1 phenotype in a variety of neurological diseases(1,2). Development of agents that could inhibit the formation of A1 reactive astrocytes could be used to treat these diseases for which there are no di...

Descripción completa

Detalles Bibliográficos
Autores principales: Yun, Seung Pil, Kam, Tae-In, Panicker, Nikhil, Kim, SangMin, Oh, Yumin, Park, Jong-Sung, Kwon, Seung-Hwan, Park, Yong Joo, Karuppagounder, Senthilkumar S., Park, Hyejin, Kim, Sangjune, Oh, Nayeon, Kim, Nayoung Alice, Lee, Saebom, Brahmachari, Saurav, Mao, Xiaobo, Lee, Jun Hee, Kumar, Manoj, An, Daniel, Kang, Sung-Ung, Lee, Yunjong, Lee, Kang Choon, Na, Dong Hee, Kim, Donghoon, Lee, Sang Hun, Roschke, Viktor V., Liddelow, Shane A., Mari, Zoltan, Barres, Ben. A., Dawson, Valina L., Lee, Seulki, Dawson, Ted M., Ko, Han Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039259/
https://www.ncbi.nlm.nih.gov/pubmed/29892066
http://dx.doi.org/10.1038/s41591-018-0051-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039259/
https://www.ncbi.nlm.nih.gov/pubmed/29892066
http://dx.doi.org/10.1038/s41591-018-0051-5

Ejemplares similares