Oxygen drives hepatocyte differentiation and phenotype stability in liver cell lines

The in vitro generation of terminally differentiated hepatocytes is an unmet need. We investigated the contribution of oxygen concentration to differentiation in human liver cell lines HepaRG and C3A. HepaRG cells were cultured under hypoxia (5%O(2)), normoxia (21%O(2)) or hyperoxia (40%O(2)). Cultu...

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Detalles Bibliográficos
Autores principales: van Wenum, Martien, Adam, Aziza A. A., van der Mark, Vincent A., Chang, Jung-Chin, Wildenberg, Manon E., Hendriks, Erik J., Jongejan, Aldo, Moerland, Perry D., van Gulik, Thomas M., Oude Elferink, Ronald P., Chamuleau, Robert A. F. M., Hoekstra, Ruurdtje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039343/
https://www.ncbi.nlm.nih.gov/pubmed/29399736
http://dx.doi.org/10.1007/s12079-018-0456-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039343/
https://www.ncbi.nlm.nih.gov/pubmed/29399736
http://dx.doi.org/10.1007/s12079-018-0456-4

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